By Thomas Ming Swi Chang
This can be a finished and primary classification evaluation of approximately all very important and basic advancements of artifiical cells by means of the nestor of this department in utilized biomedial technology himself. This "bible" is vital analyzing for either rookies and the skilled expert. Chang wrote a pretty good and stimulating evaluation over 50 years of man-made mobile learn and improvement and functions.
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Additional info for Artificial Cells: Biotechnology, Nanomedicine, Regenerative Medicine, Blood Substitutes, Bioencapsulation, Cell/Stem Cell Therapy (Regenerative Medicine, Artificial Cells and Nanomedicine)
This allows separate compartments inside the cells to carry out speciﬁc functions more effectively. , 1966) Fig. 4. Upper : Artiﬁcial cells can be prepared with intracellular multicompartments. Lower : Artiﬁcial cells containing biologics can also contain magnetic material allowing artiﬁcial cells to be site directed. Both principles are being extended by many groups and are being used in different areas of application and research. ch02 FA April 2, 2007 12:8 SPI-B446 Artiﬁcial Cells: Biotechnology, Nanotechnology, Blood Substitutes, Regenerative...
11. Other Systems As suggested earlier (Chang 1974, 1965, 1972a), the general principles of artiﬁcial cells could be explored as follows. Artiﬁcial cells containing radioactive isotopes or antimetabolites might be used for intraarterial injection into tumors. In this case, some of the microcapsules might lodge at the tumor site, while others would be carried by lymphatic channels to act on tumor cells that have metastasized to the regional lymph nodes. Artiﬁcial cells containing radiopaque material would provide a contrast medium.
1 (Continued ) 1971a Chang (Nature) Implanted enzyme AC for lymphosarcoma suppression in mice 1971b Chang Nanobiotechnology: glutaraldehyde crosslinked Hb into PolyHb. Later, others used this method for blood substitutes in patients 1972a Chang First monograph on Artiﬁcial Cells 1972b Chang (Lancet) AC hemoperfusion resulted in Grade IV hepatic coma patient recovering consciousness 1973 Gregoriadis First use of liposomes to entrap enzymes and drugs. Led to extensive development of liposomes as delivery systems 1975h Chang Paper discussing one shot vaccine using AC 1976a Chang Biodegradable polylactide microcapsules and microparticles containing proteins and hormones 1976 Tam, Blumenstein & Wong Soluble dextran conjugated hemoglobin 1976 Bonhard et al.
Artificial Cells: Biotechnology, Nanomedicine, Regenerative Medicine, Blood Substitutes, Bioencapsulation, Cell/Stem Cell Therapy (Regenerative Medicine, Artificial Cells and Nanomedicine) by Thomas Ming Swi Chang