By Irma Pereira MT (ASCP) SH, Tracy I. George MD, Daniel A. Arber MD
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Extra resources for Atlas of Peripheral Blood: The Primary Diagnostic Tool
Eds. Wintrobe’s Clinical Hematology. 12th ed. ; 2008: 1132–1142. Wang WC. Sickle cell anemia and other sickling syndromes. , eds. Wintrobe’s Clinical Hematology. 12th ed. ; 2008:1038–1082. Wilson CS, Brynes RK. Evaluation of anemia, leukopenia, and thrombocytopenia. , eds. Hematopathology. ; 2011:154–193. 4 Anemia Due to Abnormal or Impaired DNA Synthesis John Cupp, MD Anemias due to abnormal or impaired DNA synthesis can result in macrocytosis. Macrocytosis is when the mean corpuscular volume (MCV) is >100 fL for individuals >12 years of age, but this will vary when the age is <12 years.
Chapter 3: Anemia Due to Abnormal or Impaired Hemoglobin Synthesis BIBLIOGRAPHY Agarwal N, Prchal JT. Anemia of chronic disease (anemia of inflammation). Acta Haematol. 2009;122(2–3): 103–108. Barth D, Hirschmann JV. Anemia. In: Tkachuk DC, Hirschmann JV, eds. Wintrobe’s Atlas of Clinical Hematology. ; 2007:1–47. Borgna-Pignatti C, Galanello R. Thalassemias and related disorders: quantitative disorders of hemoglobin synthesis. , eds. Wintrobe’s Clinical Hematology. 12th ed. ; 2008:83–1131. Bottomley SS.
11 Hemoglobin E. In this patient who is homozygous for hemoglobin E, the RBCs show numerous target cells. RBCs are slightly microcytic and are normochromic. blister cells, and occasional “C” crystals (Fig. 13). “C” crystals are birefringent tetrahedral crystals that distort the red cell shape leaving most of the red cell clear and are composed of oxyhemoglobin. 12 Hemoglobin E and beta thalassemia. RBCs are microcytic and hypochromic with numerous target cells and nucleated RBCs. Pappenheimer bodies are frequent and polychromatophilic red cells are increased.
Atlas of Peripheral Blood: The Primary Diagnostic Tool by Irma Pereira MT (ASCP) SH, Tracy I. George MD, Daniel A. Arber MD