By Ian Tannock, Richard Hill, Robert Bristow, Lea Harrington
NOW IN complete colour!
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Here in a single well-organized, reader-friendly quantity, you will discover every little thing you want to learn about the biology underlying melanoma and its therapy, supported through the most recent peer-reviewed learn. Written by way of preeminent oncology researchers and clinicians, the booklet highlights the total variety of vital oncology subject matters and takes you thru the organic foundation of present and destiny organic treatment in addition to extra conventional methods to melanoma treatment.
Presented in complete colour, the 5th version of The simple technology of Oncology is punctiliously up-to-date and refreshed to mirror the newest severe considering in oncology. For graduate scholars, oncologists, citizens, and fellows, there will be not more worthwhile consultant to the bedrock technology and perform of oncology than this all-in-one reference.
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Extra info for Basic Science of Oncology
Here, we focus on the main approaches for studying DNA methylation along with their relative advantages and disadvantages (Table 2–3). A few points are worth emphasizing; sodium bisulfite converts unmethylated cytosines to uracil, while methylated cytosines (mC) remain unchanged (Fig. 2–20). This technique can reveal the methylation status of every cytosine residue, and it is amenable to massively parallel sequencing methods. Affinity-based methods using methyl-specific Methods of Molecular Analysis 23 TABLE 2–3 Methods for analyzing DNA methylation.
In the interim, investigators are using the NGS platforms to target specific regions of interest. This strategy can be used to examine all of the exons in the genome, specific gene families that constitute known drug targets, or megabase-size regions that are implicated in disease or pharmacogenetic effects. Methods to perform the initial first step are known as genomic partitioning and broadly include methods involving PCR, or other hybridization methodologies. These are generally hybridized to target-specific probes either on a microarray surface or in solution.
These vectors allow the manipulation of a gene, most commonly when an exogenous agent (such as tetracycline or estrogen) is added or taken away from culture media: this is achieved with a specific repressor that responds to the exogenous agent, and is fused to domains that activate the gene of interest. One method of transfection uses hydroxyethyl piperazineethanesulfonic acid (HEPES)-buffered saline solution (HeBS) containing phosphate ions combined with a calcium chloride solution containing the DNA to be transfected.
Basic Science of Oncology by Ian Tannock, Richard Hill, Robert Bristow, Lea Harrington